Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …

Although tissue homeostasis—the steady state—implies stability, our organs are in a state of
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …

A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …

Enteroendocrine cells (EEs) in the intestinal epithelium have important endocrine functions,
yet this cell lineage exhibits great local and regional variations that have hampered detailed …

It is well established that tumor necrosis factor (TNF) plays an instrumental role in
orchestrating the metabolic disorders associated with late stages of cancers. However, it is …

Bilberries (Vaccinium myrtillus L.) have been reported to hold a plentitude of health-
promoting properties beyond basic nutrition, mainly attributed to their anthocyanin content …

In response to physiological demand, the pituitary gland generates new hormone-secreting
cells from committed progenitor cells throughout life. It remains unclear to what extent …

Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation,
differentiation, and death. Deregulation of TGFβ signalling is well established in several …

Hippo signaling and the activity of its transcriptional coactivator, Yorkie (Yki), are conserved
and crucial regulators of tissue homeostasis. In the Drosophila midgut, after tissue damage …

Tumor necrosis factor (TNF)‐α is a highly conserved proinflammatory cytokine with important
functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the …