Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …

► Lipid bicelles have matured to full membership in the club of lipid phases.► Numerous
techniques have elucidated the character traits of bicelles.► Bicelles are exemplary citizens …

Magnetically aligned bicelles are an excellent medium for structure determination of
isotopically labeled membrane proteins by solid-state NMR spectroscopy. Bicelles are a …

A key factor in the development of Type II diabetes is the loss of insulin producing pancreatic
β-cells. The amyloidogenic human Islet Amyloid Polypeptide (hIAPP also known as human …

α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …

High-resolution solid-state NMR spectra can be obtained from uniformly 15N-labeled
membrane proteins in magnetically aligned bicelles. Fast uniaxial diffusion about the axis of …

Deuterium-labeled compounds are widely utilized in various scientific fields. We summarize
the recent advances in the direct deuteration of sugar, saturated fatty acid, and arene …

There is considerable interest in constructing supramolecular hollow tube architectures
based on amphiphilic molecules. This can be achieved by using relatively expensive …

Solid-state NMR is a versatile and powerful tool for determining the dynamic structure of
membrane proteins at atomic resolution. I review the recent progress in determining the …