Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …

The brain is arguably the most complex organ. The branched and extended morphology of
nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their …

Abstract Serotonin (5-HT) imbalances in the developing prefrontal cortex (PFC) are linked to
long-term behavioral deficits. However, the synaptic mechanisms underlying 5-HT-mediated …

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …

Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …

Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby
controlling neuronal excitability, firing, and plasticity. Although essential for neuronal …

Neurexins are well-characterized presynaptic cell adhesion molecules that engage
multifarious postsynaptic ligands and organize diverse synapse properties. However, the …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …

A key feature of excitatory synapses is the existence of subsynaptic protein nanoclusters
(NCs) whose precise alignment across the cleft in a transsynaptic nanocolumn influences …

As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …