Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and
chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is …

Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …

MDM2 and MDMX are the primary negative regulators of p53, which under normal
conditions maintain low intracellular levels of p53 by targeting it to the proteasome for rapid …

Background Acral melanoma is a rare type of melanoma that affects world populations
irrespective of skin color and has worse survival than other cutaneous melanomas. It has …

TP53, encoding the p53 transcription factor, is the most frequently mutated tumor suppressor
gene across all human cancer types. While p53 has long been appreciated to induce …

Inhibition of the MDM2/X-p53 interaction is recognized as a potential anti-cancer strategy,
including the treatment of glioblastoma (GB). In response to cellular stressors, such as DNA …

The mouse/murine protein, MDM2, and its human homolog, HDM2, are important negative
regulators of the p53 tumor suppressor protein. In normal, untransformed cells, MDM2 levels …

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant neuromuscular
disorder that is characterized by extreme variability in symptoms, with females being less …

Colorectal cancer (CRC) often involves wild-type p53 inactivation by MDM2 and MDM4
overexpression, promoting tumor progression and resistance to 5-fluoruracil (5-FU) …