The recently introduced open-target-controlled infusion (TCI) systems can be programmed
with any pharmacokinetic model, and allow either plasma-or effect-site targeting. With effect …

January 2016• Volume 122• Number 1 www. anesthesia-analgesia. org 57 rate will be
milligrams per kilogram per minute or micrograms per kilogram per minute. TCI systems use …

Background Unresolved issues with propofol include whether the pharmacokinetics are
linear with dose, are influenced by method of administration (bolus vs. infusion), or are …

Background Target-controlled infusion is an increasingly common type of administration for
propofol. This method requires accurate knowledge of pharmacokinetics, including the …

In order to examine whether changes in the bispectral index (BIS) may be an adequate
monitor for the analgesic component of anesthesia, we evaluated the effect of remifentanil …

Background This study investigated the effect of varying concentrations of propofol on upper
airway collapsibility and the mechanisms responsible for it. Methods Upper airway …

Background Target-controlled infusion (TCI) systems can control the concentration in the
plasma or at the site of drug effect. A TCI system that targets the effect site should be able to …

The 'Diprifusor'target controlled infusion system has been developed as a standardised
infusion system for the administration of propofol by target controlled infusion. A preferred …

BACKGROUND: Pharmacokinetic (PK) models are used to predict drug concentrations for
infusion regimens for intraoperative displays and to calculate infusion rates in target …

Many drug molecules that are currently in the market suffer from short half-life, poor
absorption, low specificity, rapid degradation, and resistance development. The design and …