Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

Typically, bovine embryos are transferred into recipient females about day 7 after estrus or
anticipated ovulation, when the embryo has reached the blastocyst stage of development …

Mitochondria play a vital role in embryo development. They are the principal site of energy
production and have various other critical cellular functions. Despite the importance of this …

Understanding human pre-implantation development has important implications for assisted
reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies …

Human reproduction is characterized by a high degree of embryo wastage, which is largely
ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies …

Development of the human placenta takes place in contrasting oxygen concentrations at
different stages of gestation, from~ 20 mmHg during the first trimester rising to~ 60 mmHg at …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …