Autoantibodies in neurological disease

H Prüss - Nature reviews immunology, 2021 - nature.com
The realization that autoantibodies can contribute to dysfunction of the brain has brought
about a paradigm shift in neurological diseases over the past decade, offering up important …

Inflammation from peripheral organs to the brain: how does systemic inflammation cause neuroinflammation?

Y Sun, Y Koyama, S Shimada - Frontiers in aging neuroscience, 2022 - frontiersin.org
As inflammation in the brain contributes to several neurological and psychiatric diseases,
the cause of neuroinflammation is being widely studied. The causes of neuroinflammation …

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

J Dalmau, T Armangué, J Planagumà… - The Lancet …, 2019 - thelancet.com
The identification of anti-NMDA receptor (NMDAR) encephalitis about 12 years ago made it
possible to recognise that some patients with rapidly progressive psychiatric symptoms or …

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Antibody-mediated encephalitis

J Dalmau, F Graus - New England Journal of Medicine, 2018 - Mass Medical Soc
Antibody-Mediated Encephalitis The category of autoimmune encephalitides constitutes
disorders with relatively distinct characteristics such as psychosis, seizures, abnormal …

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin

TA Pollak, BR Lennox, S Müller, ME Benros… - The Lancet …, 2020 - thelancet.com
There is increasing recognition in the neurological and psychiatric literature of patients with
so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) …

Immunoneuropsychiatry—novel perspectives on brain disorders

K Pape, R Tamouza, M Leboyer, F Zipp - Nature Reviews Neurology, 2019 - nature.com
Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our
cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune …

B cells in autoimmune and neurodegenerative central nervous system diseases

JJ Sabatino Jr, AK Pröbstel, SS Zamvil - Nature Reviews Neuroscience, 2019 - nature.com
B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system

J Dalmau, C Geis, F Graus - Physiological reviews, 2017 - journals.physiology.org
Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune‐associated epilepsy: conceptual definitions

C Steriade, J Britton, RC Dale, A Gadoth, SR Irani… - …, 2020 - Wiley Online Library
Seizures are a well‐recognized and often prominent manifestation of autoimmune
encephalitic syndromes. Progress in detection of pathogenic neural autoantibodies has led …