Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis
PES Munekata, M Pateiro, CA Conte-Junior… - Marine Drugs, 2021 - mdpi.com
Marine alkaloids comprise a class of compounds with several nitrogenated structures that
can be explored as potential natural bioactive compounds. The scientific interest in these …
can be explored as potential natural bioactive compounds. The scientific interest in these …
A quinquennial review on recent advancements and developments in search of anti-malarial agents
TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - ingentaconnect.com
Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …
estimated to kill between one and two million people (mainly children) every year. Novel anti …
Nanoemulsion composed of 10-(4, 5-dihydrothiazol-2-yl) thio) decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: Development, characterization, and …
MG Da Silva, JF Cardoso, FB Perasoli… - European journal of …, 2020 - Elsevier
Malaria treatment is based on a reduced number of antimalarial drugs, and drug resistance
has emerged, leading to the search for new antimalarial drugs incorporated into …
has emerged, leading to the search for new antimalarial drugs incorporated into …
In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives
This study demonstrates high drug-loading of novel pyridine derivatives (S1–S4) in lipid-and
polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and …
polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and …
Hydrazonoyl Halides as Precursors for Synthesis of Bioactive Heterocyclic Compounds via Reaction with Aryl-and Hetaryl-Amine
A literature survey revealed that a great deal of interest had been focused on the synthesis
of functionalized heterocyclic compounds due to their wide range of biological activities such …
of functionalized heterocyclic compounds due to their wide range of biological activities such …
[HTML][HTML] Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines
JT de Oliveira, FN Franco, KB Tecchio… - … /Genetic Toxicology and …, 2021 - Elsevier
The pharmacological potential of drugs must be evaluated to establish their potential
therapeutic benefits and side effects. This evaluation includes assessment of the effects of …
therapeutic benefits and side effects. This evaluation includes assessment of the effects of …
Design, synthesis and cytotoxic evaluation of 2-amino-4-aryl-6-substituted pyridine-3, 5-dicarbonitrile derivatives
Purpose: To synthesize novel pyridine derivatives and evaluate their efficiency as potent
inhibitors of cyclin dependent kinase 2 (CDK2) enzyme for cancer therapy. Methods …
inhibitors of cyclin dependent kinase 2 (CDK2) enzyme for cancer therapy. Methods …
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho-nitrobenzyl derivatives in human cancer cell lines, with and without metabolic …
J Teixeira De Oliveira, K Brito Tecchio… - Drug and Chemical …, 2024 - Taylor & Francis
Although the presence of nitro groups in chemicals can be recognized as structural alerts for
mutagenicity and carcinogenicity, nitroaromatic compounds have attracted considerable …
mutagenicity and carcinogenicity, nitroaromatic compounds have attracted considerable …
In vitro and in silico assessment of new beta amino ketones with antiplasmodial activity
GC Krombauer, KS Guedes, FF Banfi… - Revista da Sociedade …, 2022 - SciELO Brasil
Background: Based on the current need for new drugs against malaria, our study evaluated
eight beta amino ketones in silico and in vitro for potential antimalarial activity. Methods …
eight beta amino ketones in silico and in vitro for potential antimalarial activity. Methods …