For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Marine alkaloids comprise a class of compounds with several nitrogenated structures that
can be explored as potential natural bioactive compounds. The scientific interest in these …

Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Malaria treatment is based on a reduced number of antimalarial drugs, and drug resistance
has emerged, leading to the search for new antimalarial drugs incorporated into …

This study demonstrates high drug-loading of novel pyridine derivatives (S1–S4) in lipid-and
polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and …

A literature survey revealed that a great deal of interest had been focused on the synthesis
of functionalized heterocyclic compounds due to their wide range of biological activities such …

The pharmacological potential of drugs must be evaluated to establish their potential
therapeutic benefits and side effects. This evaluation includes assessment of the effects of …

Purpose: To synthesize novel pyridine derivatives and evaluate their efficiency as potent
inhibitors of cyclin dependent kinase 2 (CDK2) enzyme for cancer therapy. Methods …

Although the presence of nitro groups in chemicals can be recognized as structural alerts for
mutagenicity and carcinogenicity, nitroaromatic compounds have attracted considerable …

Background: Based on the current need for new drugs against malaria, our study evaluated
eight beta amino ketones in silico and in vitro for potential antimalarial activity. Methods …