With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient
tumors with high microsatellite instability that demonstrate immune infiltration, suggesting …

Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …

Simple Summary The extracellular matrix (ECM) is the acellular part of a tissue, a meshwork
of extracellular material produced and secreted by cells into the surrounding medium. The …

Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital
mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on …

Purpose: Recurrent tumors (RT) of head and neck squamous cell carcinoma (HNSCC) occur
in up to 60%, with poor therapeutic response and detrimental prognosis. We hypothesized …

Transfusion-related acute lung injury (TRALI) can occur during or after a transfusion, and
remains a leading cause of transfusion-associated morbidity and mortality. TRALI is caused …

The remodeling of the extracellular matrix (ECM) by several protease families releases a
number of bioactive fragments, which regulate numerous biological processes such as …