Calcium-permeable ion channels in pain signaling

E Bourinet, C Altier, ME Hildebrand… - Physiological …, 2014 - journals.physiology.org
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The role of glutamate in neuronal ischemic injury: the role of spark in fire

BB Kostandy - Neurological Sciences, 2012 - Springer
Although being a physiologically important excitatory neurotransmitter, glutamate plays a
pivotal role in various neurological disorders including ischemic neurological diseases. Its …

Thioamide‐Directed Cobalt(III)‐Catalyzed Selective Amidation of C(sp3)−H Bonds

PW Tan, AM Mak, MB Sullivan… - Angewandte Chemie …, 2017 - Wiley Online Library
A mild, oxidant‐free, and selective Cp* CoIII‐catalyzed amidation of thioamides with robust
dioxazolone amidating agents via C (sp3)− H bond activation to generate the desired …

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

A Bach, BH Clausen, M Møller… - Proceedings of the …, 2012 - National Acad Sciences
Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic
density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d …

PDZ domains as drug targets

NR Christensen, J Čalyševa… - Advanced …, 2019 - Wiley Online Library
Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

CisTrans Amide Bond Rotamers in β-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains

JS Laursen, J Engel-Andreasen, P Fristrup… - Journal of the …, 2013 - ACS Publications
Non-natural peptide analogs have significant potential for the development of new materials
and pharmacologically active ligands. One such architecture, the β-peptoids (N-alkyl-β …

Construction of Thioamide Peptides from Chiral Amino Acids

Y Liao, S Zhang, X Jiang - Angewandte Chemie International …, 2023 - Wiley Online Library
Thioamide peptides were synthesized in a straightforward one‐pot process via the linkage
of diverse natural amino acids in the presence of thiolphosphonate and trichlorosilane …

Transition Metal‐Catalyzed C− H Bond Functionalizations by Use of Sulfur‐Containing Directing Groups

KX Tang, CM Wang, TH Gao, L Chen… - Advanced Synthesis …, 2019 - Wiley Online Library
Transition metal‐catalyzed direct functionalization of C− H bonds is an economical and
efficient way to construct complex molecules that is currently attracting tremendous attention …

Three-component reaction between alkynes, elemental sulfur, and aliphatic amines: a general, straightforward, and atom economical approach to thioamides

TB Nguyen, MQ Tran, L Ermolenko… - Organic letters, 2014 - ACS Publications
Three-Component Reaction between Alkynes, Elemental Sulfur, and Aliphatic Amines: A
General, Straightforward, and Atom Economical Approach to Thioamides | Organic Letters …

Nitroalkanes as thioacyl equivalents to access thioamides and thiopeptides

X Wang, S Xu, Y Tang, MJ Lear, W He, J Li - Nature Communications, 2023 - nature.com
Thioamides are an important, but a largely underexplored class of amide bioisostere in
peptides. Replacement of oxoamide units with thioamides in peptide therapeutics is a …