Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

The S100B story: from biomarker to active factor in neural injury

F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …

Postoperative ileus and postoperative gastrointestinal tract dysfunction: pathogenic mechanisms and novel treatment strategies beyond colorectal enhanced recovery …

E Mazzotta, EC Villalobos-Hernandez… - Frontiers in …, 2020 - frontiersin.org
Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are
well-known complications affecting patients undergoing intestinal surgery. GI symptoms …

[HTML][HTML] S100B's double life: intracellular regulator and extracellular signal

R Donato, G Sorci, F Riuzzi, C Arcuri, R Bianchi… - … et Biophysica Acta (BBA …, 2009 - Elsevier
The Ca2+-binding protein of the EF-hand type, S100B, exerts both intracellular and
extracellular functions. Recent studies have provided more detailed information concerning …

Neuro-immune interactions at barrier surfaces

H Veiga-Fernandes, D Mucida - Cell, 2016 - cell.com
Multidirectional interactions between the nervous and immune systems have been
documented in homeostasis and pathologies ranging from multiple sclerosis to autism, and …

Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags

L Dayon, A Hainard, V Licker, N Turck, K Kuhn… - Analytical …, 2008 - ACS Publications
A new 6-plex isobaric mass tagging technology is presented, and proof of principle studies
are carried out using standard protein mixtures and human cerebrospinal fluid (CSF) …

The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease

M Neunlist, L Van Landeghem, MM Mahé… - Nature reviews …, 2013 - nature.com
The monolayer of columnar epithelial cells lining the gastrointestinal tract—the intestinal
epithelial barrier (IEB)—is the largest exchange surface between the body and the external …

The S100B protein in biological fluids: more than a lifelong biomarker of brain distress

F Michetti, V Corvino, MC Geloso… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation

G Esposito, E Capoccia, F Turco, I Palumbo, J Lu… - Gut, 2014 - gut.bmj.com
Objective Enteric glia activation has been reported to amplify intestinal inflammation via the
enteroglial-specific S100B protein. This neurotrophin promotes macrophage recruitment in …

Emerging roles for enteric glia in gastrointestinal disorders

KA Sharkey - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Enteric glia are important components of the enteric nervous system (ENS) and also form an
extensive network in the mucosa of the gastrointestinal (GI) tract. Initially regarded as …