ETS transcription factors: Multifaceted players from cancer progression to tumor immunity
Y Wang, Z Huang, M Sun, W Huang, L Xia - Biochimica et Biophysica Acta …, 2023 - Elsevier
The E26 transformation specific (ETS) family comprises 28 transcription factors, the majority
of which are involved in tumor initiation and development. Serving as a group of functionally …
of which are involved in tumor initiation and development. Serving as a group of functionally …
SWI/SNF blockade disrupts PU. 1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia
C Chambers, K Cermakova, YS Chan, K Kurtz… - Cancer research, 2023 - AACR
In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain
leukemic identity by driving high levels of MYC. Previous studies have implicated the …
leukemic identity by driving high levels of MYC. Previous studies have implicated the …
PU. 1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape
N Gamble, A Bradu, JA Caldwell, J McKeever… - Nature …, 2024 - nature.com
Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how
antigen recognition activates appropriate effector responses through nonspecific signaling …
antigen recognition activates appropriate effector responses through nonspecific signaling …
Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis
The transcriptional repressor ZEB2 regulates development of many cell fates among
somatic, neural, and hematopoietic lineages, but the basis for its requirement in these …
somatic, neural, and hematopoietic lineages, but the basis for its requirement in these …
Cis-regulatory evolution of the recently expanded Ly49 gene family
C Fan, X Xing, SJH Murphy, J Poursine-Laurent… - Nature …, 2024 - nature.com
Comparative genomics has revealed the rapid expansion of multiple gene families involved
in immunity. Members within each gene family often evolved distinct roles in immunity …
in immunity. Members within each gene family often evolved distinct roles in immunity …
Baf155 controls hematopoietic differentiation and regeneration through chromatin priming
Chromatin priming promotes cell-type-specific gene expression, lineage differentiation, and
development. The mechanism of chromatin priming has not been fully understood. Here, we …
development. The mechanism of chromatin priming has not been fully understood. Here, we …
Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling
CHD8 is an ATP-dependent chromatin-remodeling factor whose monoallelic mutation
defines a subtype of autism spectrum disorders (ASDs). Previous work found that CHD8 is …
defines a subtype of autism spectrum disorders (ASDs). Previous work found that CHD8 is …
BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
W Fiskus, J Piel, M Collins, M Hentemann, B Cuglievan… - Blood, 2024 - ashpublications.org
Abstract BRG1 (SMARCA4) and BRM (SMARCA2) are the mutually exclusive core ATPases
of the chromatin remodeling BAF (BRG1/BRM-associated factor) complexes. They enable …
of the chromatin remodeling BAF (BRG1/BRM-associated factor) complexes. They enable …
Hijacking the transcriptional activation potential of the BAF complex via Induced Proximity
The BAF (Brg/Brahma-associated factors) complex, also referred to as the mammalian
Switch/Sucrose-Nonfermentable (mSWI/SNF) chromatin remodeling complex, plays a …
Switch/Sucrose-Nonfermentable (mSWI/SNF) chromatin remodeling complex, plays a …
Loss of Bicra/Gltscr1 leads to a defect in fetal liver macrophages responsible for erythrocyte maturation in mice.
GLTSCR1, a protein encoded by the Bicra gene, is a defining subunit of the SWI/SNF (also
called mammalian BAF) chromatin remodeling subcomplex called GBAF/ncBAF. To …
called mammalian BAF) chromatin remodeling subcomplex called GBAF/ncBAF. To …