Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Impulsivity is strongly associated with substance use disorders (SUDs). Our review
discusses impulsivity as an underlying vulnerability marker for SUDs, and treatment of co …

Context An association between dopamine-replacement therapies and impulse control
disorders (ICDs) in Parkinson disease (PD) has been suggested in preliminary studies …

Context Attention-deficit/hyperactivity disorder (ADHD)—characterized by symptoms of
inattention and hyperactivity-impulsivity—is the most prevalent childhood psychiatric …

The involvement of dopamine in drug reinforcement is well recognized but its role in drug
addiction is much less clear. Imaging studies have shown that the reinforcing effects of drugs …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

The striatum acts in conjunction with the cortex to control and execute functions that are
impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and …

[11C]-(+)-PHNO is a D3 preferring PET radioligand which has recently opened the
possibility of imaging D3 receptors in the human brain in vivo. This imaging tool allows …

The human striatum is functionally organized into limbic, associative, and sensorimotor
subdivisions, which process information related to emotional, cognitive, and motor function …

Dopamine transmission in the ventral striatum (VST), a structure which includes the nucleus
accumbens, ventral caudate, and ventral putamen, plays a critical role in the …