Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia
which is caused by insufficient insulin secretion or insulin resistance. Interaction of genetic …

Pancreatic neuroendocrine neoplasms (pNENs) are rare cancers with broad challenges for
their management. The main clinical obstacles are the high rate of patients diagnosed at …

Purpose: As noninvasive biomarkers are an important unmet need for neuroendocrine
neoplasms (NEN), biomarker potential of genome-wide molecular profiling of plasma cell …

Despite numerous observations regarding the relationship between DNA methylation
changes and cancer progression, only a few genes have been verified as diagnostic …

Transcription factors (TFs) are essential for proper activation of gene during the process of
organogenesis, differentiation, lineage specificity. Reactivation or dysregulation of TFs …

Insulinomas are rare functional pancreatic neuroendocrine tumors. While most insulinomas
are indolent and cured after surgery, 10-15% of cases show aggressive or malignant tumor …

Primary non‐functional pancreatic neuroendocrine tumors (NF‐PanNETs) are a
heterogeneous group of neuroendocrine neoplasms that display highly variable clinical …

Neuroendocrine neoplasms are a diverse group of neoplasms that originate from cells in the
diffuse neuroendocrine system. These unique neoplasms can arise in almost every organ in …

Gastric cancer (GC) is a common malignant tumor, which has a high incidence and fatality.
Therefore, it is important to clarify the molecular mechanism of the occurrence and …

Graphical abstract Abstract The 5th edition of the World Health Organization (WHO)
classification of neuroendocrine neoplasms (NENs) is built to achieve a uniform terminology …