Preclinical studies coupled with clinical pharmacologic and neuroimaging investigations
have advanced our understanding of brain circuits that modulate pain. Descending pain …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has
been proposed to identify quiescent and tumor growth–sustaining stem cells. DCLK1+ tuft …

The existence of adult pancreatic progenitor cells has been debated. While some favor the
concept of facultative progenitors involved in homeostasis and repair, neither a location nor …

Cancer pain significantly affects the diagnosis, quality of life and survival of patients with
cancer. During the past decade, preclinical and clinical data has begun to provide insight …

Pain is a highly complex and subjective experience that is not linearly related to the
nociceptive input. What is clear from anecdotal reports over the centuries and more recently …

BACKGROUND: The actions of endogenous opioid peptides are mediated by 3 main
classes of opioid receptors; mu (MOR), kappa (KOR), and delta (DOR). METHODS: We …

Perineural tumor invasion of intrapancreatic nerves, neurogenic inflammation, and tumor
metastases along extrapancreatic nerves are key features of pancreatic malignancies …

Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …

Cancer cachexia is a complex metabolic disorder accounting for~ 20% of cancer-related
deaths, yet its metabolic landscape remains unexplored. Here, we report a decrease in B …