An intricate molecular machinery is at the core of gene expression regulation in every cell.
During the initial stages of organismal development, the coordinated activation of diverse …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …

The cancer stem cell hypothesis posits that malignant growth arises from a rare population
of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such …

The CpG island methylator phenotype is characterized by DNA hypermethylation in the
promoters of several suppressor genes associated with the inactivation of various pathways …

A series of Δ2-isoxazoline constrained analogues of procaine/procainamide (7a–k and 8a–
k) were prepared and their inhibitory activity against DNA methyltransferase 1 (DNMT1) was …

Similar to genetic alterations, epigenetic aberrations contribute significantly to tumor
initiation and progression. In many cases, these changes are caused by activation or …

Abstract CD133 (prominin-1) is a member of the transmembrane glycoprotein family and
was initially described as a specific marker to select human hematopoietic progenitor cells …

Abstract Interleukin-6 (IL-6), involved in cancer-related inflammation, acts as an autocrine
and paracrine growth factor, which promotes angiogenesis, metastasis, and subversion of …

CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively
modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear …

Tumours were recently revealed to undergo a phylostratic and phenotypic shift to
unicellularity. As well, aggressive tumours are characterized by an increased proportion of …