Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …

Protein–protein interactions are vital to biological processes, but the shape and size of their
interfaces make them hard to target using small molecules. Cyclic peptides have shown …

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

The research of integrin-targeted anticancer agents has recorded important advancements
in ingenious design of delivery systems, based either on the prodrug approach, or on …

Poor penetration of antitumor drugs into the extravascular tumor tissue is often a major factor
limiting the efficacy of cancer treatments. Our group has recently described a strategy to …

A growing body of evidence suggests that peptides containing the Asn-Gly-Arg (NGR) motif
can selectively recognize tumor neovasculature and can be used, therefore, for ligand …

Delivery and penetration of chemotherapeutic drugs into tumors are limited by a number of
factors related to abnormal vasculature and altered stroma composition in neoplastic …

Aging results from the accumulation of molecular damage that impairs normal biochemical
processes. We previously reported that age‐linked damage to amino acid sequence NGR …

Integrins are cell-adhesion receptors that mediate cell–extracellular-matrix (ECM) and cell–
cell interactions by recognizing specific ligands. Recent studies have shown that the …