Photochemical approaches to complex chemotypes: applications in natural product synthesis

MD Karkas, JA Porco Jr, CRJ Stephenson - Chemical Reviews, 2016 - ACS Publications
The use of photochemical transformations is a powerful strategy that allows for the formation
of a high degree of molecular complexity from relatively simple building blocks in a single …

Recent advances in the synthesis of cyclobutanes by olefin [2+ 2] photocycloaddition reactions

S Poplata, A Tröster, YQ Zou, T Bach - Chemical Reviews, 2016 - ACS Publications
The [2+ 2] photocycloaddition is undisputedly the most important and most frequently used
photochemical reaction. In this review, it is attempted to cover all recent aspects of [2+ 2] …

Strategic application of C–H oxidation in natural product total synthesis

I Bakanas, RF Lusi, S Wiesler… - Nature Reviews …, 2023 - nature.com
The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural
product synthesis and has altered how chemists approach the synthesis of complex …

Oxetanes: recent advances in synthesis, reactivity, and medicinal chemistry

JA Bull, RA Croft, OA Davis, R Doran… - Chemical …, 2016 - ACS Publications
The four-membered oxetane ring has been increasingly exploited for its contrasting
behaviors: its influence on physicochemical properties as a stable motif in medicinal …

Photochemical reactions as key steps in natural product synthesis

T Bach, JP Hehn - Angewandte Chemie International Edition, 2011 - Wiley Online Library
Photochemical reactions contribute in a significant way to the existing repertoire of carbon–
carbon bond‐forming reactions by allowing access to exceptional molecular structures that …

Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

R Long, J Huang, J Gong, Z Yang - Natural Product Reports, 2015 - pubs.rsc.org
Covering: 2000 to 2015 Molecules containing vicinal all-carbon quaternary stereocenters
are found in many secondary metabolites, and they exhibit a variety of biological and …

Terpenoids with special pharmacological significance: A review

R Jaeger, E Cuny - Natural product communications, 2016 - journals.sagepub.com
Terpenoids are a very prominent class of natural compounds produced in diverse genera of
plants, fungi, algae and sponges. They gained significant pharmaceutical value since …

Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes

K Hung, ML Condakes, LFT Novaes… - Journal of the …, 2019 - ACS Publications
The Illicium sesquiterpenes are a family of natural products containing over 100 highly
oxidized and structurally complex members, many of which display interesting biological …

Neurotrophic natural products: chemistry and biology

J Xu, MH Lacoske… - Angewandte Chemie …, 2014 - Wiley Online Library
Neurodegenerative diseases and spinal cord injury affect approximately 50 million people
worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous …

Photochemische Reaktionen als Schlüsselschritte in der Naturstoffsynthese

T Bach, JP Hehn - Angewandte Chemie, 2011 - Wiley Online Library
Photochemische Reaktionen bereichern in signifikanter Weise das Repertoire zur Knüpfung
von Kohlenstoff‐Kohlenstoff‐Bindungen und machen ungewöhnliche, auf herkömmlichem …