Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development

PA Rice, WM Shafer, S Ram… - Annual review of …, 2017 - annualreviews.org
Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains
resistant to many antibiotics are emerging. Appropriate antimicrobial treatment and …

Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube

JD Lenz, JP Dillard - Frontiers in immunology, 2018 - frontiersin.org
Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface
infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva …

Progress toward a gonococcal vaccine: the way forward

MW Russell, AE Jerse, SD Gray-Owen - Frontiers in immunology, 2019 - frontiersin.org
The concept of immunizing against gonorrhea has received renewed interest because of the
recent emergence of strains of Neisseria gonorrhoeae that are resistant to most currently …

Epidemiology, Treatments, and Vaccine Development for Antimicrobial-Resistant Neisseria gonorrhoeae: Current Strategies and Future Directions

EY Lin, PC Adamson, JD Klausner - Drugs, 2021 - Springer
Neisseria gonorrhoeae is the second most common bacterial sexually transmitted infection
in the world after Chlamydia trachomatis. The pathogen has developed resistance to every …

Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae

JS Stevens, AK Criss - Current opinion in hematology, 2018 - journals.lww.com
Pathogenesis of Neisseria gonorrhoeae in the female reproduc... : Current Opinion in
Hematology Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract …

The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus

A Vrbanac, AM Riestra, A Coady, R Knight, V Nizet… - BMC microbiology, 2018 - Springer
Background Composition of the vaginal microbiota has significant influence on female
urogenital health and control of infectious disease. Murine models are widely utilized to …

[HTML][HTML] Sex-dependent astrocyte reactivity: Unveiling chronic stress-induced morphological changes across multiple brain regions

AY Zhang, E Elias, MT Manners - Neurobiology of disease, 2024 - Elsevier
Chronic stress is a major precursor to various neuropsychiatric disorders and is linked with
increased inflammation in the brain. However, the bidirectional association between …

Is female health cyclical? Evolutionary perspectives on menstruation

A Alvergne, VH Tabor - Trends in ecology & evolution, 2018 - cell.com
Why do some females menstruate at all? Answering this question has implications for
understanding the tight links between reproductive function and organismal immunity. Here …

Th1-polarized MtrE-based gonococcal vaccines display prophylactic and therapeutic efficacy

S Song, S Wang, X Jiang, F Yang, S Gao… - Emerging Microbes & …, 2023 - Taylor & Francis
Global dissemination of high-level ceftriaxone-resistant Neisseria gonorrhoeae strains
associated with the FC428 clone poses a threat to the efficacy ceftriaxone-based therapies …

The cycling and aging mouse female reproductive tract at single-cell resolution

I Winkler, A Tolkachov, F Lammers, P Lacour… - Cell, 2024 - cell.com
The female reproductive tract (FRT) undergoes extensive remodeling during reproductive
cycling. This recurrent remodeling and how it shapes organ-specific aging remains poorly …