Synapses are functionally distinct neuronal compartments that are critical for brain function,
with synaptic dysfunction being an early pathological feature in aging and disease. Given …

Circular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting
as a special covalent loop without a 5′ cap or 3′ tail. Multiple biological properties of …

Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment
epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …

Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying
pathogenic mechanisms in these diseases may offer global approaches for facilitating …

Aging contributes to the appearance of several retinopathies and is the largest risk factor for
aged‐related macular degeneration, major cause of blindness in the elderly population …

The behavioral consequences of age-related alterations in neural function are well
documented, but less is known about their cellular bases. To characterize such changes, we …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark …

Background Aging is associated with functional decline of neurons and increased incidence
of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila …

Age-related decreases in neural function result in part from alterations in synapses. To
identify molecular defects that lead to such changes, we focused on the outer retina, in …

Methylation of the regulatory region of the elongation of very‐long‐chain fatty acids‐like 2
(ELOVL2) gene, an enzyme involved in elongation of long‐chain polyunsaturated fatty …