Dynamic modulation of protein levels is tightly controlled in response to physiological cues.
In mammalian cells, much of the protein degradation is carried out by the ubiquitin …

Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …

KRAS is mutated in∼ 20% of human cancers and is one of the most sought-after targets for
pharmacological modulation, despite having historically been considered “undruggable.” …

The removal of unwanted or damaged mitochondria by autophagy, a process called
mitophagy, is essential for key events in development, cellular homeostasis, tumor …

The current predominant therapeutic paradigm is based on maximizing drug-receptor
occupancy to achieve clinical benefit. This strategy, however, generally requires excessive …

Abstract PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules
that recruit an E3 ubiquitin ligase to a given substrate protein resulting in its targeted …

The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional
activity using competitive antagonists, such as enzalutamide remains a frontline therapy for …

Inhibition of Bruton's tyrosine kinase (BTK) with the irreversible inhibitor ibrutinib has
emerged as a transformative treatment option for patients with chronic lymphocytic leukemia …

Small molecule-induced protein degradation is an attractive strategy for the development of
chemical probes. One method for inducing targeted protein degradation involves the use of …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …