A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Several genes that predispose to type 2 diabetes have recently been identified. In addition
to the recognized and powerful effects of environmental factors, there is abundant evidence …

Most diabetes-related complications and causes of death arise from cardiovascular disease
and end-stage renal disease. Amongst the major complications of diabetes mellitus are …

Depression, type 2 diabetes (T2D), and metabolic syndrome (MetS) are often comorbid.
Depression per se increases the risk for T2D by 60%. This risk is not accounted for by the …

Globally, chronic kidney disease (CKD) contributes substantial morbidity and mortality.
Recently, various 'omics platforms have provided insight into the molecular basis of kidney …

Increased oxidative stress and activation of protein kinase C (PKC) under hyperglycemia
have been implicated in the development of diabetic nephropathy. Because reactive oxygen …

Africa is the ultimate source of modern humans and as such harbors more genetic variation
than any other continent. For this reason, studies of the patterns of genetic variation in …

Candidate-gene association studies that examined the association between polymorphisms
of endothelial nitric oxide synthase (NOS3) gene (G894T, 4b/a, and T786C) and diabetic …

Abstract Background Serum creatinine (S CR) is the most important biomarker for a quick
and non-invasive assessment of kidney function in population-based surveys. A substantial …