Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …

Millions of protein molecules are synthesized per minute in each cell, and simultaneously,
millions of protein molecules are degraded. Mutated and misfolded newly synthesized …

Reactive oxygen species (ROS) play important roles in cell signaling and tissue
homeostasis, in which the level of ROS is critical through the equilibrium between ROS …

Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the
treatment of numerous malignancies. The primary dose-limiting adverse effect of …

The heart is highly sensitive to the aging process. In the elderly, the heart tends to become
hypertrophic and fibrotic. Stiffness increases with ensuing systolic and diastolic dysfunction …

Abstract Background Muscle ring finger 1 (MuRF1) is a muscle‐specific ubiquitin E3 ligase
activated during clinical conditions associated with skeletal muscle wasting. Yet, there …

Rationale: Previous studies have suggested that myocardial inflammation plays a critical
role after ischemic myocardial infarction (MI); however, the underlying mechanisms still need …

Mammalian target of rapamycin (mTOR) is an evolutionary conserved kinase that senses the
nutrient and energy status of cells, the availability of growth factors, stress stimuli and other …

Autophagy is involved in the development and/or progression of many diseases, including
myocardial ischemia/reperfusion (I/R). In this study, we hypothesized a protective role of …