Although the incidence of Pneumocystis pneumonia (PCP) has decreased since the
introduction of combination antiretroviral therapy, it remains an important cause of disease in …

Laboratory mice, rats, and rabbits may harbor a variety of viral, bacterial, parasitic, and
fungal agents. Frequently, these organisms cause no overt signs of disease. However, many …

Objective This study was conducted to evaluate the efficacy and safety of repeated and
prolonged B cell depletion with rituximab (RTX) for the maintenance of long‐term remission …

After more than 10 years of use, rituximab has proven to be remarkably safe. However,
accumulated evidence now suggests that under some circumstances it may significantly …

The fungal infection Pneumocystis pneumonia is the most prevalent opportunistic infection
in patients with AIDS. Although the analysis of this opportunistic fungal pathogen has been …

Innate immune mechanisms against Pneumocystis carinii, a frequent cause of pneumonia in
immunocompromised individuals, are not well understood. Using both real time polymerase …

B cell-deficient mice are susceptible to infection by Pneumocystis carinii f. sp. muris (PC). To
determine whether this susceptibility is due to a requirement for B cells to prime T cells, we …

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that
deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and …

Pneumocystis pneumonia (PCP) is a major cause of morbidity and mortality among
immunocompromised persons, and it remains a leading acquired immune deficiency …

Host defenses are profoundly compromised in HIV-infected hosts due to progressive
depletion of CD4+ T lymphocytes. Moreover, deficient CD4+ T lymphocytes impair …