Catalytic transformations involving metal carbenes are considered one of the most important
aspects of homogeneous transition metal catalysis. Recently, gold-catalyzed generation of …

Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

A software framework is introduced that facilitates the application of biasing algorithms to
collective variables of the type commonly employed to drive massively parallel molecular …

Isoxazoles are important five‐membered aromatic heterocycles in organic chemistry.
Recently, many exciting advances in the synthesis and functionalization of isoxazoles have …

Highlights•Approval of first endonuclease inhibitor for influenza treatment.•Represents a
new class of influenza drug.•Single dose is clinically effective.For the first time in nearly 20 …

Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …

Nature often uses cascade reactions in a highly stereocontrolled manner for assembly
structurally diverse nitrogen-containing heterocyclic scaffolds, ie secondary metabolites …

Isoxazoles, as masked 1, 3-dicarbonyl equivalents, have proven to be versatile building
blocks and pivotal intermediates for the construction of a variety of useful azacycles with …

Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar
functionality, a small-molecule approach is often viewed as insufficient to achieve high …

Two new gold‐catalyzed annulations of isoxazoles with propiolates have been developed.
Most isoxazoles follow an initial O attack on the alkyne to afford a [4+ 1] annulation product …