Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …

Background: Because acute liver failure is rare, related data have been sparse. Studies
have suggested that viral hepatitis is the most common underlying cause of this condition …

Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We
determined the incidence, risk factors, and outcomes of acetaminophen‐induced ALF at 22 …

Drug-induced hepatic injury accounts for more than 50 percent of cases of acute liver failure
in the United States. More than 75 percent of idiosyncratic drug reactions result in liver …

We provide a demonstration in humans of the principle of pharmacometabonomics by
showing a clear connection between an individual's metabolic phenotype, in the form of a …

Acetaminophen (APAP) is a safe and effective analgesic and antipyretic. 1 It is widely
available as a single-component medication and also as a component of a plethora of …

Acetaminophen (APAP or paracetamol or N-acetyl-p-aminophenol), a safe and effective
antipyretic and analgesic, has been extensively used around the world since 1955. It is …