[HTML][HTML] Acetaminophen-induced hepatotoxicity: a comprehensive update
E Yoon, A Babar, M Choudhary, M Kutner… - Journal of clinical and …, 2016 - ncbi.nlm.nih.gov
Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis
MR McGill, H Jaeschke - Pharmaceutical research, 2013 - Springer
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
RJ Fontana, I Liou, A Reuben, A Suzuki, MI Fiel… - Hepatology, 2023 - journals.lww.com
There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses
LL Mazaleuskaya, K Sangkuhl, CF Thorn… - Pharmacogenetics …, 2015 - journals.lww.com
Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
G Ostapowicz, RJ Fontana, FV Schiødt… - Annals of internal …, 2002 - acpjournals.org
Background: Because acute liver failure is rare, related data have been sparse. Studies
have suggested that viral hepatitis is the most common underlying cause of this condition …
have suggested that viral hepatitis is the most common underlying cause of this condition …
[PDF][PDF] Acetaminophen‐induced acute liver failure: results of a United States multicenter, prospective study
AM Larson, J Polson, RJ Fontana, TJ Davern… - …, 2005 - Wiley Online Library
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We
determined the incidence, risk factors, and outcomes of acetaminophen‐induced ALF at 22 …
determined the incidence, risk factors, and outcomes of acetaminophen‐induced ALF at 22 …
Drug-induced hepatotoxicity
WM Lee - New England journal of medicine, 2003 - Mass Medical Soc
Drug-induced hepatic injury accounts for more than 50 percent of cases of acute liver failure
in the United States. More than 75 percent of idiosyncratic drug reactions result in liver …
in the United States. More than 75 percent of idiosyncratic drug reactions result in liver …
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
We provide a demonstration in humans of the principle of pharmacometabonomics by
showing a clear connection between an individual's metabolic phenotype, in the form of a …
showing a clear connection between an individual's metabolic phenotype, in the form of a …
A review of acetaminophen poisoning
MJ Hodgman, AR Garrard - Critical care clinics, 2012 - criticalcare.theclinics.com
Acetaminophen (APAP) is a safe and effective analgesic and antipyretic. 1 It is widely
available as a single-component medication and also as a component of a plethora of …
available as a single-component medication and also as a component of a plethora of …
Acetaminophen-related hepatotoxicity
C Bunchorntavakul, KR Reddy - Clinics in liver disease, 2013 - liver.theclinics.com
Acetaminophen (APAP or paracetamol or N-acetyl-p-aminophenol), a safe and effective
antipyretic and analgesic, has been extensively used around the world since 1955. It is …
antipyretic and analgesic, has been extensively used around the world since 1955. It is …