[HTML][HTML] Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders
Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …
[HTML][HTML] Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …
continue to pose a significant risk to human health. This is due to not only the continued …
PTEN in autism and neurodevelopmental disorders
S Rademacher, BJ Eickholt - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes
phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong …
phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong …
[HTML][HTML] Polychlorinated biphenyls (PCBs): risk factors for autism spectrum disorder?
HK Panesar, CL Kennedy, KP Keil Stietz, PJ Lein - Toxics, 2020 - mdpi.com
Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental
disorders defined clinically by core deficits in social reciprocity and communication …
disorders defined clinically by core deficits in social reciprocity and communication …
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice
Fragile X syndrome results from a loss of the RNA-binding protein fragile X mental
retardation protein (FMRP). How FMRP regulates neuronal development and function …
retardation protein (FMRP). How FMRP regulates neuronal development and function …
The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences
Although banned from production for decades, PCBs remain a significant risk to human
health. A primary target of concern is the developing brain. Epidemiological studies link PCB …
health. A primary target of concern is the developing brain. Epidemiological studies link PCB …
Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies
The pathological alterations that manifest during the early embryonic development due to
inherited and acquired factors trigger various neurodevelopmental disorders (NDDs) …
inherited and acquired factors trigger various neurodevelopmental disorders (NDDs) …
Phosphodiesterase type 4 inhibition in CNS diseases
A Blokland, P Heckman, T Vanmierlo… - Trends in …, 2019 - cell.com
Phosphodiesterases (PDEs) have been an interesting drug target for many diseases.
Although a vast number of mainly preclinical studies demonstrates beneficial effects of PDE …
Although a vast number of mainly preclinical studies demonstrates beneficial effects of PDE …
[HTML][HTML] Multiple behavior phenotypes of the fragile-X syndrome mouse model respond to chronic inhibition of phosphodiesterase-4D (PDE4D)
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum
disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene …
disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene …
[HTML][HTML] The molecular functions of MeCP2 in Rett syndrome pathology
MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription.
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …