Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …

In the last decades, nanotechnology-based tools started to draw the attention of research
worldwide. They offer economic, rapid, effective, and highly specific solutions for most …

Semiconductor quantum dots and nanoparticles composed of metals, lipids or polymers
have emerged with promising applications for early detection and therapy of cancer …

Under appropriate conditions, block copolymeric macroamphiphiles will self-assemble in
water to form vesicles, referred to as polymersomes. We report here polymersomes that can …

Human plasmacytoid dendritic cells (PDCs) can produce interferon (IFN)-α and/or mature
and participate in the adaptive immune response. Three classes of CpG oligonucleotide …

Parasitic diseases such as malaria, leishmaniasis, and trypanosomiasis represent a
significant global burden and pose a great challenge to drug discovery and delivery …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

Introduction: A century after its discovery, American trypanosomiasis or Chagas disease
remains a serious health problem in Latin America, where it affects around 7–8 million …

While small hydrophilic therapeutic molecules have proved to be exceptionally effective in
curing diseases, their in vivo efficacy remains low. Small molecule therapeutics infused in …

Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma
cruzi. After a mostly clinically silent acute phase, the disease becomes a lifelong chronic …