A subset of hereditary and sporadic colorectal carcinomas is defined by microsatellite
instability (MSI), but the spectra of gene mutations have not been characterized extensively …

Though most colorectal cancers show allelic losses, a subset of colorectal cancers
(microsatellite instability or MSI-positive cancers) develop numerous small insertion and …

Bcl-2 is known to inhibit apoptosis and is thought to play a role in colorectal tumour
development. Studies of the promoter region of bcl-2 have indicated the presence of a p53 …

Microsatellite instability (MSI) characterizes the hereditary nonpolyposis colorectal cancer
syndrome but is also found in sporadic tumors. Frameshifts in microsatellites found in the …

Up to 15% of all colorectal cancers are considered to be replication error positive (RER+)
and contain mutations at hundreds of thousands of microsatellite repeat sequences …

We have identified a novel gene, EMSl, that is consistently amplified and overexpressed in
human carcinomas with an amplification of the chromosome 11q13 region. Comparisons of …

Although microsatellite instability (MSI) has been shown to be present in 15% of sporadic
colorectal carcinomas, the genetic events underlying the development of these tumors have …

Microsatellite instability (MI+) is associated with defects in mismatch repair, resulting in a
'mutator'phenotype and the development and progression of cancer. MI+ has been …

Purpose: To determine whether pretreatment plasma-transforming growth factor beta 1
(TGFβ1) levels are prognostic for tumor control and late morbidity following radiation therapy …

It has been recognized that gastric cancer often shows histological heterogeneity in a single
tumor. Although microsatellite instability (MSI) has been reported in gastric cancer, the …