Oxidative stress, inflammation, and vascular aging in hypertension

TJ Guzik, RM Touyz - Hypertension, 2017 - Am Heart Assoc
Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22
Perivascular fibrosis is greatly dependent on immune cells because it is prevented in …

The role of adipose tissue in cardiovascular health and disease

EK Oikonomou, C Antoniades - Nature Reviews Cardiology, 2019 - nature.com
Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …

The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

XC Li, J Zhang, JL Zhuo - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

The role of infiltrating immune cells in dysfunctional adipose tissue

TJ Guzik, DS Skiba, RM Touyz… - Cardiovascular …, 2017 - academic.oup.com
Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Perivascular adipose tissue inflammation in vascular disease

R Nosalski, TJ Guzik - British journal of pharmacology, 2017 - Wiley Online Library
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in …

COVID-19 and hypertension: the what, the why, and the how

SA Muhamad, A Ugusman, J Kumar, D Skiba… - Frontiers in …, 2021 - frontiersin.org
It has been a year since the coronavirus disease 2019 (COVID-19) was declared pandemic
and wreak havoc worldwide. Despite meticulous research has been done in this period …

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …

The role of oxidative stress in cardiovascular aging and cardiovascular diseases

C Izzo, P Vitillo, P Di Pietro, V Visco, A Strianese… - Life, 2021 - mdpi.com
Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

The anti-inflammatory effect of taurine on cardiovascular disease

T Qaradakhi, LK Gadanec, KR McSweeney… - Nutrients, 2020 - mdpi.com
Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With
its unique sulfonic acid makeup, taurine influences cellular functions, including …