Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …

A wide range of diseases have been shown to be influenced by the accumulation of
senescent cells, from fibrosis to diabetes, cancer, Alzheimer's and other age-related …

Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

Cellular senescence is a terminal differentiation state that has been proposed to have a role
in both tumour suppression and ageing. This view is supported by the fact that accumulation …

Cellular senescence arrests the proliferation of potential cancer cells, and so is a potent
tumor suppressive mechanism, akin to apoptosis. Or is it? Why did cells evolve an anti …

The systemic regulation of stem cells ensures that they meet the needs of the organism
during growth and in response to injury. A key point of regulation is the decision between …

Sperm and egg production requires a robust stem cell system that balances self-renewal
with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis …

The past decade of research on Drosophila stem cells and niches has provided key insights.
Fly stem cells do not occupy a special" state" based on novel" stem cell genes" but resemble …

Ageing is accompanied by a progressive decline in stem cell function, resulting in less
effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that …