How transcription factors drive choice of the T cell fate
H Hosokawa, EV Rothenberg - Nature Reviews Immunology, 2021 - nature.com
Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …
in the thymus and undergo commitment to become T cells. Together with environmental …
TCF1 in T cell immunity: a broadened frontier
TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …
downstream of the WNT signalling pathway and are essential for early T cell development …
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
F Alfei, K Kanev, M Hofmann, M Wu, HE Ghoneim… - Nature, 2019 - nature.com
Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
Integrative bulk and single-cell profiling of premanufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy
The adoptive transfer of chimeric antigen receptor (CAR) T cells represents a breakthrough
in clinical oncology, yet both between-and within-patient differences in autologously derived …
in clinical oncology, yet both between-and within-patient differences in autologously derived …
[HTML][HTML] Master transcription factors and mediator establish super-enhancers at key cell identity genes
Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
[HTML][HTML] The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
[HTML][HTML] Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
SK Ahuja, MS Manoharan, GC Lee… - Nature …, 2023 - nature.com
Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …
WNT signaling in cancer immunosurveillance
Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …
progression, and resistance to conventional cancer therapy in a variety of preclinical and …
[HTML][HTML] LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
YS Choi, JA Gullicksrud, S Xing, Z Zeng, Q Shan… - Nature …, 2015 - nature.com
Follicular helper T cells (T FH cells) are specialized effector CD4+ T cells that help B cells
develop germinal centers (GCs) and memory. However, the transcription factors that …
develop germinal centers (GCs) and memory. However, the transcription factors that …
Tcf1–CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis
CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that
transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of …
transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of …