Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade
J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …
A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders
The extracellular matrix (ECM) is a critical regulator of neural network development and
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its …
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its …
[HTML][HTML] Next generation matrix metalloproteinase inhibitors—Novel strategies bring new prospects
Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for
tissue homeostasis and cell signaling. These proteolytic activities are mediated …
tissue homeostasis and cell signaling. These proteolytic activities are mediated …
Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with …
A Arjunan, DK Sah, M Woo, J Song - Cell & Bioscience, 2023 - Springer
Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …
Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine
Y Yao, C Wang - NPJ Regenerative medicine, 2020 - nature.com
Cell dedifferentiation is the process by which cells grow reversely from a partially or
terminally differentiated stage to a less differentiated stage within their own lineage. This …
terminally differentiated stage to a less differentiated stage within their own lineage. This …
Matrix metalloproteinase-2 and-9 as promising benefactors in development, plasticity and repair of the nervous system
M Verslegers, K Lemmens, I Van Hove… - Progress in neurobiology, 2013 - Elsevier
It has been 50years since Gross and Lapiere discovered collagenolytic activity during
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …
A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline
In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …
Inflammation and matrix metalloproteinase 9 (Mmp‐9) regulate photoreceptor regeneration in adult zebrafish
Brain injury activates complex inflammatory signals in dying neurons, surviving neurons,
and glia. Here, we establish that inflammation regulates the regeneration of photoreceptors …
and glia. Here, we establish that inflammation regulates the regeneration of photoreceptors …
Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9
Lack of target specificity by existing matrix metalloproteinase (MMP) inhibitors has hindered
antimetastatic cancer drug discovery. Inhibitors that bind to noncatalytic sites of MMPs and …
antimetastatic cancer drug discovery. Inhibitors that bind to noncatalytic sites of MMPs and …
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration
Y Kim, AG Remacle, AV Chernov, H Liu, I Shubayev… - PloS one, 2012 - journals.plos.org
Background Myelinating Schwann cells (mSCs) form myelin in the peripheral nervous
system. Because of the works by us and others, matrix metalloproteinase-9 (MMP-9) has …
system. Because of the works by us and others, matrix metalloproteinase-9 (MMP-9) has …