Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Reactive oxygen species are constantly produced in aerobic organisms as by-products of
normal oxygen metabolism and include free radicals such as superoxide anion (O 2−) and …

Oxidative stress is a key feature in the Alzheimer's disease (AD) brain and manifests as lipid
peroxidation (LPO). Isoprostanes (iPs) are specific and sensitive markers of in vivo LPO. To …

The amyloid-β precursor protein (APP) is directly and efficiently cleaved by caspases during
apoptosis, resulting in elevated amyloid-β (Aβ) peptide formation. The predominant site of …

Melatonin, a pineal gland synthesized neurohormone is known as a multifunctioning
pleiotropic agent which has a wide range of neuroprotective role in manifold age-related …

Increased awareness for a role of oxidative stress in the pathogenesis of Alzheimer's
disease has highlighted the issue of whether oxidative damage is a fundamental step in the …

Previous evidence has indicated that the neuronal toxicity of amyloid β (βA) protein is
mediated through oxygen free radicals and can be attenuated by antioxidants and free …

Recently an aspartyl protease with β-secretase activity called BACE was identified. In the
present paper we showed that BACE is modulated by the oxidative stress product 4 …

Apoptosis is now recognized as a normal feature in the development of the nervous system
and may also play a role in neurodegenerative diseases and aging. This phenomenon has …

Increased levels of a 40–42 amino‐acid peptide called the amyloid β protein (Aβ) and
evidence of oxidative damage are early neuropathological markers of Alzheimer's disease …