A central role of brain mitochondria in regulating and influencing social behaviour is
emerging. In addition to its important roles as the “powerhouses” of the cell, mitochondria …

Early life experiences have a significant influence on adult health and aging processes in
humans. Despite widespread interest in the evolutionary roots of this phenomenon, very little …

Epigenetic factors modify the effects of environmental factors on biological outcomes.
Identification of epigenetic changes that associate with PTSD is therefore a crucial step in …

Abstract Background Adverse childhood experiences (ACEs) increase the risk of poor health
outcomes later in life. Psychosocial stressors may also have intergenerational health effects …

This study aimed to improve our understanding of how the hypothalamus mediates the
effects of prenatal and postnatal challenges on behavior and sensitivity to stimuli. A pig …

Almost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the
significance of cilia, once considered vestigial organelles, in the higher-order brain functions …

The purpose of this study was to explore the metabolomic differences between Major
depressive disorder (MDD) and healthy individuals among adolescents and the association …

Circadian rhythms are a foundational aspect of biology. These rhythms are found at the
molecular level in every cell of every living organism and they play a fundamental role in …

Background: Sexual and physical abuse have been associated with long-term systemic
alterations such as low-grade inflammation and changes in brain morphology that may be …

Voltage-gated potassium (Kv) channels formed by α subunits KCNQ2-5 are important in
regulating neuronal excitability. We previously found that GABA directly binds to and …