The root cause of sickle cell disease is a single β‐globin gene mutation coding for the sickle
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by microvascular
vaso-occlusion with erythrocytes containing polymerized sickle (S) hemoglobin, erythrocyte …

Pain is the leading cause of emergency department visits, hospitalizations, and daily
suffering in individuals with sickle cell disease (SCD). The pathologic mechanisms leading …

Aim: To report on molecular mechanisms of fetal hemoglobin (HbF) induction by
hydroxyurea (HU) for the treatment of sickle cell disease. Study Design: Systematic review …

Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and
nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular …

Sickle cell disease (SCD) had first been mentioned in the literature a century ago.
Advancement in the molecular basis of the pathophysiology of the disease opens the door …

Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell
anemia (SCA). However, little is known about the HU NO-related effects on red blood cell …

Endothelial dysfunction is associated with decreased NO bioavailability and impaired
activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in …

Platelets are specialized adhesive cells that play a key role in normal and pathological
hemostasis through their ability to rapidly adhere to subendothelial matrix proteins (platelet …

Sickle cell disease is a systemic disorder that is caused by a mutation (Glu6Val) in the gene
that encodes β globin. The sickle hemoglobin molecule (HbS) is a tetramer of two α-globin …