Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: a review

J Sadri Nahand, M Moghoofei… - … journal of cancer, 2020 - Wiley Online Library
Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most
important risk factor for the development of CC is cervical infection with human papilloma …

The role of nuclear factor-kappa B signaling in human cervical cancer

S Tilborghs, J Corthouts, Y Verhoeven, D Arias… - Critical reviews in …, 2017 - Elsevier
Abstract Background The Nuclear Factor kappaB (NF-kB) family consists of transcription
factors that play a complex and essential role in the regulation of immune responses and …

[HTML][HTML] Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway

M Li, C Wu, JS Muhammad, D Yan, K Tsuneyama… - Redox biology, 2020 - Elsevier
Recent research suggests that melatonin (Mel), an endogenous hormone and natural
supplement, possesses anti-proliferative effects and can sensitise cells to anti-cancer …

Therapeutic effects of natural products on cervical cancer: based on inflammatory pathways

ZW Zhou, HZ Long, SG Xu, FJ Li, Y Cheng… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a protective response of the body to an irritant. When an inflammatory
response occurs, immune cells are recruited to the injury, eliminating the irritation. The …

The interplay between viruses and TRIM family proteins

R Khan, A Khan, A Ali, M Idrees - Reviews in medical virology, 2019 - Wiley Online Library
Novel therapeutic options are urgently needed to improve the global treatment of viral
infections. Tripartite motif (TRIM) family proteins are involved in various biological and …

Advances in exosome biomarkers for cervical cancer

Z Ran, S Wu, Z Ma, X Chen, J Liu, J Yang - Cancer medicine, 2022 - Wiley Online Library
Cervical cancer (CC) ranks as the fourth most frequently diagnosed malignancy in females
worldwide. Exosomes are a subclass of extracellular vesicles released by nearly all types of …

miR‐214 activates TP53 but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical and colorectal cancer cells

KS Chandrasekaran… - Cell Biochemistry …, 2017 - Wiley Online Library
High Mobility Group AT‐hook 1 (HMGA1) was identified as a target of miR‐214 in human
cervical and colorectal cancers (CaCx and CRC) in a previous study. While the expression …

Human papillomavirus 16 E2 as an apoptosis-inducing protein for cancer treatment: a systematic review

DF Jamal, QA Rozaimee, NH Osman… - International Journal of …, 2022 - mdpi.com
Human papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and
oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV–16 …

HPV-mediated resistance to TNF and TRAIL is characterized by global alterations in apoptosis regulatory factors, dysregulation of death receptors, and induction of …

TK Cabeça, A de Mello Abreu, R Andrette… - International journal of …, 2019 - mdpi.com
Persistent infection with high-risk human papilloma virus (HR-HPV) is the main risk factor for
the development of invasive cervical cancer although is not sufficient to cause cervical …

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

Y He, Y Qiu, X Yang, G Lu, SS Zhao - Seminars in Cancer Biology, 2024 - Elsevier
Cellular senescence is a response to various stress signals, which is characterized by stable
cell cycle arrest, alterations in cellular morphology, metabolic reprogramming and …