Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular
matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans …

Exuberant fibroproliferation is a common complication after injury for reasons that are not
well understood. One key component of wound repair that is often overlooked is mechanical …

Scars caused by skin injuries after burns, wounds, abrasions and operations have serious
physical and psychological effects on patients. In recent years, the research of scar free …

Following skin wounding, the healing outcome can be: regeneration, repair with normal scar
tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical …

Skin injury is a common occurrence and mechanical forces are known to significantly impact
the biological processes of skin regeneration and wound healing. Immediately following the …

Fibrosis is a dynamic process with the potential for reversibility and restoration of near-
normal tissue architecture and organ function. Herein, we review mechanisms for resolution …

Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent
studies indicate that mechanical force significantly impacts wound healing and skin …

Recent evidence suggests that mechanical forces can significantly impact the biologic
response to injury. Integrated mechanical and chemical signaling networks have been …

Pathological scarring imposes a major clinical and social burden worldwide. Human
cutaneous wounds are responsive to mechanical forces and convert mechanical cues to …