Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …

ABSTRACT SARS-CoV-2 can enter cells after its spike protein is cleaved by either type II
transmembrane serine proteases (TTSPs), like TMPRSS2, or cathepsins. It is now widely …

The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans
and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis …

The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-
spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing
global pandemic associated with morbidity and mortality in humans. Although disease …

The COVID-19 pandemic remains a global health threat and novel antiviral strategies are
urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into …