Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

S Sakaue, S Gurajala, M Curtis, Y Luo, W Choi… - Nature protocols, 2023 - nature.com
The human leukocyte antigen (HLA) locus is associated with more complex diseases than
any other locus in the human genome. In many diseases, HLA explains more heritability …

SNP‐HLA Reference Consortium (SHLARC): HLA and SNP data sharing for promoting MHC‐centric analyses in genomics

N Vince, V Douillard, E Geffard, D Meyer… - Genetic …, 2020 - Wiley Online Library
Genome‐wide associations studies have repeatedly identified the major histocompatibility
complex genomic region (6p21. 3) as key in immune pathologies. Researchers have also …

[PDF][PDF] HLA Allele Type Prediction: A Review on Concepts, Methods and Algorithms

B Sivaprakasam, P Sadagopan - Asian Journal of Biological and Life …, 2023 - ajbls.com
ABSTRACT The Human Leukocyte Antigen (HLA) gene system situated on Chromosome 6
has been the subject of extensive research, primarily due to its vital role in transplantation …

In silico tools and databases for designing cancer immunotherapy

A Dhall, S Jain, N Sharma, LD Naorem, D Kaur… - Advances in Protein …, 2022 - Elsevier
Immunotherapy is a rapidly growing therapy for cancer which have numerous benefits over
conventional treatments like surgery, chemotherapy, and radiation. Overall survival of …

Imputation HLA dans des populations d'ancestralité composite grâce à des méthodes de réduction de dimension

V Douillard - 2022 - theses.hal.science
La génomique humaine a rapidement évolué cette dernière décennie grâce aux avancées
technologiques de génotypage et de séquençage, permettant l'essor des études …

[PDF][PDF] Integrated Web Application (Snips2HLA-HsG) Development for Sample Preparation and Model Creation for HLA Allele Prediction with the SNP Data Using …

B Sivaprakasam, P Sadagopan - 2024 - lidsen.com
The present study introduces Snips2HLA-HsG, an integrated application designed for SNP
genotype analysis and HLA allele type prediction. Leveraging attribute bagging, a powerful …