Metal–curcumin complexes in therapeutics: an approach to enhance pharmacological effects of curcumin

S Prasad, D DuBourdieu, A Srivastava… - International journal of …, 2021 - mdpi.com
Curcumin, an active component of the rhizome turmeric, has gained much attention as a
plant-based compound with pleiotropic pharmacological properties. It possesses anti …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

The incretin hormone GLP‐1 and mechanisms underlying its secretion: 肠促胰岛素激素GLP‐1 及其潜在的分泌机制

L Tian, T Jin - Journal of diabetes, 2016 - Wiley Online Library
摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是一种细胞类型特异性的胰高血糖
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …

Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy

Y Lu, D Zhu, Q Le, Y Wang, W Wang - Nanoscale, 2022 - pubs.rsc.org
Ruthenium complex is an important compound group for antitumor drug research and
development. NAMI-A, KP1019, TLD1433 and other ruthenium complexes have entered …

Natural phenolic compounds potentiate hypoglycemia via inhibition of Dipeptidyl peptidase IV

PK Huang, SR Lin, CH Chang, MJ Tsai, DN Lee… - Scientific Reports, 2019 - nature.com
Abstract Dipeptidyl peptidase IV (DPP IV) is a surface glycoprotein that can degrade
glucagon like pepetide-1 (GLP-1) by decreasing blood sugar. Herbal medicines for diabetic …

Nanogels, nanodiscs, yeast cells, and metallo-complexes-based curcumin delivery for therapeutic applications

M Rahmanian, F Oroojalian, E Pishavar… - European Polymer …, 2023 - Elsevier
Curcumin extracted from the rhizomes of Curcuma longa and widely used because of its
biological advantages such as anti-inflammatory, anti-cancer, anti-oxidant, anti-ageing, anti …

Synthesis, structure, and anticancer activity of arene–ruthenium (II) complexes with acylpyrazolones bearing aliphatic groups in the acyl moiety

J Palmucci, F Marchetti, R Pettinari, C Pettinari… - Inorganic …, 2016 - ACS Publications
A series of neutral ruthenium (II) arene complexes [(arene) Ru (QR) Cl](arene= p-cymene
(cym) or hexamethylbenzene (hmb)) containing 4-acyl-5-pyrazolonate QR ligands with …

A ruthenium (II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

A Garufi, S Baldari, R Pettinari… - Journal of Experimental …, 2020 - Springer
Background Tumor progression and tumor response to anticancer therapies may be affected
by activation of oncogenic pathways such as the antioxidant one induced by NRF2 (nuclear …

The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin …

NJ Sadgrove - Journal of ethnopharmacology, 2018 - Elsevier
Ethnopharmacological relevance Research in the past half a century has gradually sketched
the biological mechanism leading to androgenetic alopecia (AGA). Until recently the …

Ruthenium compounds as potential therapeutic agents for type 2 diabetes mellitus

S Maikoo, D Makayane, IN Booysen, P Ngubane… - European Journal of …, 2021 - Elsevier
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder which is globally
responsible for millions of fatalities per year. Management of T2DM typically involves orally …