It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs,
and disease states are connected by virtue of common gene-expression signatures. Here …

Little is known about how metabolites couple tissue-specific stem cell function with
physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 …

Expression of PD-1 ligands by tumors and interaction with PD-1–expressing T cells in the
tumor microenvironment can result in tolerance. Therapies targeting this coinhibitory axis …

Abstract TP53 (p53) is the most frequently mutated gene in cancer, being altered in
approximately 50% of human malignancies. In most, if not all, cancers lacking mutation, wild …

Background Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial
cells in the bronchial mucosa. Changes in their integrity might play a role in asthma …

Histone deacetylases are key enzymes of epigenetic regulation and are therefore involved
in crucial cellular events like transcription, differentiation, apoptosis and cell division. The …

Mutations in the TP53 gene are a feature of 50% of all reported cancer cases. In the other
50% of cases, the TP53 gene itself is not mutated but the p53 pathway is often partially …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …