Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder, in which multiple risk
factors converge. Despite the complexity of the etiology of the disease, synaptic failure is the …

Diverse translational and research applications could benefit from the noninvasive ability to
reversibly modulate (excite or suppress) CNS activity using ultrasound pulses, however …

The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose
and lipid metabolism and, importantly, it has critical roles in the brain ranging from its …

The smooth endoplasmic reticulum (SER) is a well-characterized buffer and source of Ca 2+
in both axonal and dendritic compartments of neurons. Ca 2+ release from the SER can be …

In neurons, as in other excitable cells, mitochondria extrude Ca2+ ions from their matrix in
exchange with cytosolic Na+ ions. This exchange is mediated by a specific transporter …

Previous studies indicate that boutons from the same axon exhibit distinct Ca 2+ dynamics
depending on the postsynaptic targets. Mossy fibers of hippocampal granule cells innervate …

While neuronal mitochondria have been studied extensively in their role in health and
disease, the rules that govern calcium regulation in mitochondria remain somewhat vague …

Mitochondria sequester much of the Ca2+ that enters motor nerve terminals during repetitive
stimulation at frequencies exceeding 10–20 Hz. We studied the post‐stimulation extrusion of …

Intracellular calcium stores control many neuronal functions such as excitability, gene
expression, synaptic plasticity, and synaptic release. Although the existence of calcium …