Dengue, caused by infection of any of four dengue virus serotypes (DENV-1 to DENV-4), is a
mosquito-borne disease of major public health concern associated with significant morbidity …

Dengue is the world's most prevalent and important arboviral disease. More than 50% of the
world's population lives at daily risk of infection and it is estimated more than 95 million …

Background In efficacy trials of a tetravalent dengue vaccine (CYD-TDV), excess
hospitalizations for dengue were observed among vaccine recipients 2 to 5 years of age …

Dengue is a major global public health problem requiring a safe and efficacious vaccine as
the foundation of a comprehensive countermeasure strategy. Despite decades of attempts …

Background A candidate tetravalent dengue vaccine is being assessed in three clinical trials
involving more than 35,000 children between the ages of 2 and 16 years in Asian–Pacific …

Dengue viruses have spread rapidly within countries and across regions in the past few
decades, resulting in an increased frequency of epidemics and severe dengue disease …

Zika virus is a member of the Flavivirus genus that had not been associated with severe
disease in humans until the recent outbreaks, when it was linked to microcephaly in …

Vaccination has made an enormous contribution to global health. Two major infections,
smallpox and rinderpest, have been eradicated. Global coverage of vaccination against …

Background In light of the increasing rate of dengue infections throughout the world despite
vector-control measures, several dengue vaccine candidates are in development. Methods …

Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For
some patients, dengue is a life-threatening illness. There are currently no licensed vaccines …