Objective: Machine learning classification has been the most important computational
development in the last years to satisfy the primary need of clinicians for automatic early …

Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Objective Alzheimer disease (AD) is characterized by functional impairment in the neural
elements and circuits underlying cognitive and memory functions. We hypothesized that …

Amyloid deposition is present in 20–50% of nondemented older adults yet the functional
consequences remain unclear. The current study found that amyloid accumulation is …

The factors driving clinical heterogeneity in Alzheimer's disease are not well understood.
This study assessed the relationship between amyloid deposition, glucose metabolism and …

We report a group of patients presenting with a progressive dementia syndrome
characterized by predominant dysfunction in core executive functions, relatively young age …

It is “normal” for old age to be associated with gradual decline in memory and brain mass.
However, there are anecdotal reports of individuals who seem immune to age-related …

A central issue in cognitive neuroscience of aging research is pinpointing precise neural
mechanisms that determine cognitive outcome in late adulthood as well as identifying early …

A 72-year-old man seeks consultation at the urging of his wife for increasing difficulty with
memory over the past 2 years. Clients at his brokerage firm have expressed concern about …

A number of functional magnetic resonance imaging (fMRI) studies reported the existence of
default mode network (DMN) and its disruption due to the presence of a disease such as …