More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …

Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …

Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature
of neurodegenerative diseases. There is a lack of strategies that target dendritic and …

Purpose.: To investigate the potential therapeutic benefit of intravitreally implanted dental
pulp stem cells (DPSCs) on axotomized adult rat retinal ganglion cells (RGCs) using in vitro …

Genetic medicine is offering hope as new therapies are emerging for many previously
untreatable diseases. The eye is at the forefront of these advances, as exemplified by the …

Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family
and has been implicated in both apoptotic and non-apoptotic signaling pathways, including …