An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Environmental enrichment (EE) is an environmental paradigm encompassing sensory,
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …

Obesity is a risk factor for cognitive dysfunction and neurodegenerative disease, including
Alzheimer's disease (AD). The gut microbiota-brain axis is altered in obesity and linked to …

Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Some recent studies have highlighted a link between a favorable childhood environment
and the strengthening of neuronal resilience against the changes that occur in natural aging …

The brain is the most energy-consuming organ of the body and impairments in brain energy
metabolism will affect neuronal functionality and viability. Brain aging is marked by defects in …

Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease (AD) risk.
Acute exercise reduces the activity of β-site amyloid precursor protein-cleaving enzyme 1 …

Scope Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can
influence cerebral physiology, but the effect of western diets on brain cholesterol …

Abstract Effects of enriched environment (EE) combined with fluoxetine in a chronic
unpredictable stress (CUS) rat model were examined in our study. Thirty male Sprague …

High-fat diet (HFD) has been associated with neuroinflammation and apoptosis in distinct
brain regions. To explore the effect of short-term (7, 14 and 21 days) high-fat overfeeding on …