TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
The effects of early life stress on the epigenome: from the womb to adulthood and even before
N Provençal, EB Binder - Experimental neurology, 2015 - Elsevier
Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …
established major risk factor for developing psychiatric and behavioral disorders later in life …
Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2
DNA methylation at CpG dinucleotides is an important epigenetic regulator common to
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …
Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice
The RNA modification N 6-methyladenosine (m6A) influences mRNA stability and cell-type-
specific developmental programming, and is highly abundant in the adult brain. However, it …
specific developmental programming, and is highly abundant in the adult brain. However, it …
[HTML][HTML] Tet2 rescues age-related regenerative decline and enhances cognitive function in the adult mouse brain
Restoring adult stem cell function provides an exciting approach for rejuvenating the aging
brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive …
brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive …
EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life
experience is translated into storable epigenetic information remains largely unknown. With …
experience is translated into storable epigenetic information remains largely unknown. With …
Epigenetic regulations in neuropsychiatric disorders
Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …
proper brain development, function and circuitry formation in the mammalian central nervous …
How the epigenome integrates information and reshapes the synapse
RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …
encodes information to form long-lasting memories that lead to stable changes in behaviour …