Transcription regulation by the Mediator complex
J Soutourina - Nature reviews Molecular cell biology, 2018 - nature.com
Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …
developmental diseases or cancer. Transcription activation is a key phenomenon in the …
[HTML][HTML] Transcriptional regulation and its misregulation in disease
TI Lee, RA Young - Cell, 2013 - cell.com
The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …
Structures of the human Mediator and Mediator-bound preinitiation complex
INTRODUCTION The multisubunit Mediator binds RNA polymerase II (Pol II), transduces
regulatory signals from transcription factors to Pol II, facilitates preinitiation complex (PIC) …
regulatory signals from transcription factors to Pol II, facilitates preinitiation complex (PIC) …
Computational tools for prioritizing candidate genes: boosting disease gene discovery
Y Moreau, LC Tranchevent - Nature Reviews Genetics, 2012 - nature.com
At different stages of any research project, molecular biologists need to choose—often
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …
The Mediator complex: a master coordinator of transcription and cell lineage development
J Yin, G Wang - Development, 2014 - journals.biologists.com
Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase
II. Multiple subunits of the complex show specificity in relaying information from signals and …
II. Multiple subunits of the complex show specificity in relaying information from signals and …
Core Mediator structure at 3.4 Å extends model of transcription initiation complex
Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC)
and regulates RNA polymerase (Pol) II,,. The Mediator head and middle modules form the …
and regulates RNA polymerase (Pol) II,,. The Mediator head and middle modules form the …
Classification, diagnosis and potential mechanisms in pontocerebellar hypoplasia
Y Namavar, PG Barth, BT Poll-The, F Baas - Orphanet journal of rare …, 2011 - Springer
Pontocerebellar Hypoplasia (PCH) is group of very rare, inherited progressive
neurodegenerative disorders with prenatal onset. Up to now seven different subtypes have …
neurodegenerative disorders with prenatal onset. Up to now seven different subtypes have …
Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures
Progressive microcephaly is a heterogeneous condition with causes including mutations in
genes encoding regulators of neuronal survival. Here, we report the identification of …
genes encoding regulators of neuronal survival. Here, we report the identification of …
Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
H Zhao, N Young, J Kalchschmidt, J Lieberman… - Nature …, 2021 - nature.com
The Mediator complex plays an essential and multi-faceted role in regulation of RNA
polymerase II transcription in all eukaryotes. Structural analysis of yeast Mediator has …
polymerase II transcription in all eukaryotes. Structural analysis of yeast Mediator has …
Unraveling the molecular pathogenesis of Type 2 Diabetes and its impact on female infertility: A bioinformatics and systems biology approach
Type 2 diabetes mellitus (T2D) has been linked with female infertility (FI). Nevertheless, our
understanding of the molecular hallmarks and underlying mechanisms remains elusive. This …
understanding of the molecular hallmarks and underlying mechanisms remains elusive. This …