Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …

Intestinal health relies on the immunosuppressive activity of CD4+ regulatory T (Treg) cells.
Expression of the transcription factor Foxp3 defines this lineage, and can be induced …

The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …

The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …

Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

The mucosal immune system of neonates goes through successive, non-redundant phases
that support the developmental needs of the infant and ultimately establish immune …

The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In
addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IEC s) …

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …